Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
2.
Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model.
Drug Metab Dispos
; 50(7): 980-988, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35545257
3.
Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP).
Xenobiotica
; 48(5): 467-477, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485193
4.
Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.
Xenobiotica
; 48(11): 1173-1183, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29098941
5.
Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.
Bioorg Med Chem Lett
; 26(2): 551-555, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26642765
6.
Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist).
AAPS J
; 24(6): 99, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36123502
7.
Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J Med Chem
; 64(5): 2501-2520, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33631934
8.
Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions.
Drug Metab Dispos
; 38(9): 1612-22, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516252
9.
Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling.
AAPS J
; 18(6): 1512-1523, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27600136